A DIRECTED BIOSYNTHESIS FOR AN IMMUNOMYCIN DERIVATIVE

This invention relates to a novel process for producing a new proline derivative of immunomycin (FK-520), designated "prolyl-immunomycin" that has immunosuppressant activity. This process involves directed biosynthesis, a fermentation process in which a cultured Streptomyces organism, e.g....

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Bibliographische Detailangaben
Hauptverfasser:	BYRNE, KEVIN, M, KAPLAN, LOUIS, ARISON, BYRON H, DUMONT, FRANCIS, KAHN, JENNIFER N
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	This invention relates to a novel process for producing a new proline derivative of immunomycin (FK-520), designated "prolyl-immunomycin" that has immunosuppressant activity. This process involves directed biosynthesis, a fermentation process in which a cultured Streptomyces organism, e.g. Streptomyces hygroscopicus subsp. ascomyceticus, ATCC 55087, is grown in the presence of proline or its salts as biosynthetic precursors.