Aromatase inhibiting 4(5)-imidazoles
Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond an...
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| creator | LAMMINTAUSTA, RISTO ARVO SAKARI KALAPUDAS, ARJA MARKETTA PELKONEN, REINO OLAVI KARJALAINEN, ARTO JOHANNES SODERVALL, MARJA-LIISA LAHDE, MATTI ANTERO |
| description | Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH). |
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Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).</description><edition>5</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951115&DB=EPODOC&CC=EP&NR=0476944B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951115&DB=EPODOC&CC=EP&NR=0476944B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LAMMINTAUSTA, RISTO ARVO SAKARI</creatorcontrib><creatorcontrib>KALAPUDAS, ARJA MARKETTA</creatorcontrib><creatorcontrib>PELKONEN, REINO OLAVI</creatorcontrib><creatorcontrib>KARJALAINEN, ARTO JOHANNES</creatorcontrib><creatorcontrib>SODERVALL, MARJA-LIISA</creatorcontrib><creatorcontrib>LAHDE, MATTI ANTERO</creatorcontrib><title>Aromatase inhibiting 4(5)-imidazoles</title><description>Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBxLMrPTSxJLE5VyMzLyEzKLMnMS1cw0TDV1M3MzUxJrMrPSS3mYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgEGJuZmliYmTobGRCgBAIhCJdM</recordid><startdate>19951115</startdate><enddate>19951115</enddate><creator>LAMMINTAUSTA, RISTO ARVO SAKARI</creator><creator>KALAPUDAS, ARJA MARKETTA</creator><creator>PELKONEN, REINO OLAVI</creator><creator>KARJALAINEN, ARTO JOHANNES</creator><creator>SODERVALL, MARJA-LIISA</creator><creator>LAHDE, MATTI ANTERO</creator><scope>EVB</scope></search><sort><creationdate>19951115</creationdate><title>Aromatase inhibiting 4(5)-imidazoles</title><author>LAMMINTAUSTA, RISTO ARVO SAKARI ; KALAPUDAS, ARJA MARKETTA ; PELKONEN, REINO OLAVI ; KARJALAINEN, ARTO JOHANNES ; SODERVALL, MARJA-LIISA ; LAHDE, MATTI ANTERO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0476944B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1995</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LAMMINTAUSTA, RISTO ARVO SAKARI</creatorcontrib><creatorcontrib>KALAPUDAS, ARJA MARKETTA</creatorcontrib><creatorcontrib>PELKONEN, REINO OLAVI</creatorcontrib><creatorcontrib>KARJALAINEN, ARTO JOHANNES</creatorcontrib><creatorcontrib>SODERVALL, MARJA-LIISA</creatorcontrib><creatorcontrib>LAHDE, MATTI ANTERO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LAMMINTAUSTA, RISTO ARVO SAKARI</au><au>KALAPUDAS, ARJA MARKETTA</au><au>PELKONEN, REINO OLAVI</au><au>KARJALAINEN, ARTO JOHANNES</au><au>SODERVALL, MARJA-LIISA</au><au>LAHDE, MATTI ANTERO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Aromatase inhibiting 4(5)-imidazoles</title><date>1995-11-15</date><risdate>1995</risdate><abstract>Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Aromatase inhibiting 4(5)-imidazoles |
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