Aromatase inhibiting 4(5)-imidazoles

Aromatase inhibiting 4(5)-imidazoles

Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond an...

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Hauptverfasser: LAMMINTAUSTA, RISTO ARVO SAKARI, KALAPUDAS, ARJA MARKETTA, PELKONEN, REINO OLAVI, KARJALAINEN, ARTO JOHANNES, SODERVALL, MARJA-LIISA, LAHDE, MATTI ANTERO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Novel imidazole derivatives of the formula wherein R1, R2, R min 1 and R min 2, which can be the same or different, are H,CH3, C2H5, C3H7, OCH3, NO2, NH2, CN, CF3, CHF2, CHF2 or halogen; R min is H or where R3 is H, CH3 or halogen; R4 is H or OH and R5 is H or OH or R4 and R5 together form a bond and n is 1 to 4, and their non-toxic salts exhibit aromatase and desmolase inhibiting properties. Selective aromatase inhibiting compounds are valuable in the treatment of estrogen dependent diseases, e.g. breast cancer or benign prostatic hyperplasia (BPH).