Derivatives of 4-(2,4-difluoro-biphenylyl)-2-methyl-4-oxo-butanoic acid

This invention relates to substances represented by Formula (I), wherein X stands for either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which R is an alkyl of 1 to 4 carbon atoms, or a (CH2)nNR'2 group wherein n is 2 or 3 while R' is a methyl or ethyl group; eventually X m...

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Bibliographische Detailangaben
Hauptverfasser: POPPOVA, MARIE, KUCHAR, MIROSLAV, GRIMOVA, JAROSLAVA, MATUROVA, EVA
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:This invention relates to substances represented by Formula (I), wherein X stands for either OR in which R is an alkyl of 1 to 4 carbon atoms, or NHR in which R is an alkyl of 1 to 4 carbon atoms, or a (CH2)nNR'2 group wherein n is 2 or 3 while R' is a methyl or ethyl group; eventually X may represent morpholinyl. Also considered are salts of 4-(2,4-difluorobiphenylyl)-2-methyl-4-oxobutanoic acid with appropriate inorganic or organic bases represented by Formula (II) wherein B is either an alkaline metal cation, alkaline earth cation, cyclohexylamine cation, or lysine cation. Said substances are characterized by anti-inflammatory properties comparable to (and greater than) the initial acid while simultaneously said modifications of their physico-chemical properties broaden the possibilities of their therapeutic application.