ASSAY METHOD USING SURFACE PLASMON RESONANCE SPECTROMETRY

In an assay for an analyte, particularly a hapten, changes in refractive index at a solid surface are monitored by means of surface plasmon resonance spectroscopy. The signal is enhanced by conjugating to an assay reagent a substance capable of giving a strong signal. One example is an enzyme used t...

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Bibliographische Detailangaben
Hauptverfasser:	CHARLES, STEPHEN ALEXANDER, FINLAN, MARTIN FRANCIS, GARLAND, PETER BRYAN, POLLARD-KNIGHT, DENISE VERA
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING PHYSICS TESTING
Online-Zugang:	Volltext bestellen
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Beschreibung
Zusammenfassung:	In an assay for an analyte, particularly a hapten, changes in refractive index at a solid surface are monitored by means of surface plasmon resonance spectroscopy. The signal is enhanced by conjugating to an assay reagent a substance capable of giving a strong signal. One example is an enzyme used to catalyse production of an insoluble product. Another example is latex beads. Assay formats include sandwich assay format, and a competition assay format preferably involving displacement of the conjugate.