ALLELIC VARIANTS OF -I(PLASMODIUM FALCIPARUM) MEROZOITE SURFACE ANTIGEN

A merozoite surface antigen of Plasmodium falciparum selected from the class characterised by: (i) having a relative molecular mass, Mr, (determined by SDS-polyacrylamide gel electrophoresis) in the range of approximately 41,000 to 53,000; and (ii) comprising multiple allelic forms of MSA2, having c...

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Bibliographische Detailangaben
Hauptverfasser:	CHEE, DAVID, WAI, WING, COPPEL, ROSS, LEON, IRVING, DAVID, OWEN, SAUL, ALLAN, JAMES, KEMP, DAVID, JAMES, ANDERS, ROBIN, FREDERIC, SMYTHE, JASON, ARTHUR, GOSS, NEIL, HOWARD, JONES, GRAHAM, LLOYD, DYER, SANDRA, LEIGH
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A merozoite surface antigen of Plasmodium falciparum selected from the class characterised by: (i) having a relative molecular mass, Mr, (determined by SDS-polyacrylamide gel electrophoresis) in the range of approximately 41,000 to 53,000; and (ii) comprising multiple allelic forms of MSA2, having conserved N-terminal and C-terminal sequences; or an antigenic fragment thereof. Particular antigenic fragments include sequence corresponding to repeat sequences and sequences from conserved N-terminal and C-terminal regions. Production of antigens by recombinant DNA techniques as fusion and non-fusion proteins, and use in vaccine compositions is also disclosed.