Condensed pyrimidine derivates

Compounds of the formula (1): wherein one or two of A, B, E, or D are N, and the others are CR or A, E, and D are N and B is CR ; where R and R are independently H, halo, (C1-C4) alkyl, (C3-C4) branched alkyl, (C1-C4) alkoxy, halo (C1-C4) alkyl, phenyl, or substituted phenyl; X is O, S, SO, SO2, NR , or CR R , where R is H, (C1-C4) alkyl, or (C1-C4) acyl, and R and R are independently H, (C1-C4) acyl, (C1-C4) alkyl, (C2-C4) alkenyl or -alkynyl, CN, or OH, or R and R combine to form a carbocyclic ring containing four to six carbon atoms; Y is a bond or an alkylene chain one to six carbon atoms long, optionally including a carbocyclic ring, and optionally including a hetero atom selected from O, NR , S, SO, SO2, or SiR R , where R is as defined above and R and R are independently (C1-C4) alkyl, (C3-C4) branched alkyl, phenyl, or substituted phenyl, and optionally substituted with (C1-C4) alkyl, (C2-C4) alkenyl or -alkynyl, branched (C3-C7) alkyl, (C3-C7) cycloalkyl or -cycloalkenyl, halo, hydroxy, or acetyl, and Z is (a) a C1-C12 saturated or unsaturated hydrocarbon chain, straight chain or branched optionally including a hetero atom selected from O, S, SO, SO2, or SiR R , where R and R are as defined above, and optionally substituted with halo, halo (C1-C4) alkoxy, hydroxy, (C3-C8) cycloalkyl or cycloalkenyl, or (C1-C4) acyl; (b) (C3-C8) cycloalkyl or cycloalkenyl, optionally substituted with (C1-C4) alkyl, (C1-C4) alkoxy, halo (C1-C4) alkyl, halo (C1-C4) alkoxy, halo, hydroxy, or (C1-C4) acyl; (c) a phenyl group of the formula (2) where R to R are independently H. halo, I, (C1-C10) alkyl, (C3-C8) alkenyl or -alkynyl, branched (C3-C6) alkyl, -alkenyl, or -alkynyl, (C3-C8) cycloalkyl or -cycloalkenyl, ha]o (C1-C7) alkyl, (C1-C7) alkoxy, (C1-C7) alkylthio, halo (C1-C7) alkoxy, phenoxy, substituted phenoxy, phenylthio, substituted phenylthio, phenyl, substituted phenyl, NO2, acetoxy, OH, CN, SiR R R , OSiR R R , NR R , S(O)R , or SO2R where R , R , and R are independently (C1-C4) alkyl, (C3-C4) branched alkyl, phenyl, or substituted phenyl, R and R are independently H, (C1-C4) alkyl, or (C1-C4) acyl, and R and R are (C1-C10) alkyl, phenyl, or substituted phenyl; (d) a furyl group of formula (3) where R is H, halo, halomethyl, CN, NO2, (C1-C4) alkyl, (C3-C4) branched alkyl, phenyl, or (C1-C4) alkoxy; (e) a thienyl group of the formula (4) where R is as defined in paragraph (d); (f) a group of formula (5) or (6) where R is as defined in paragraph (d), J is N or