Method for producing synthetic N-linked glycoconjugates

Method for producing synthetic N-linked glycoconjugates

A method is disclosed for derivatizing oligosaccharides to form synthetic N-linked glycoconjugates by converting a glycosylamine derivative of the oligosaccharide to a haloacetylated derivative as an intermediate compound prior to formation of the synthetic N-linked glycoconjugate to thereby maintai...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: MANGER, IAN DAVID, DWEK, RAYMOND ALLEN, RADEMACHER, THOMAS WILLIAM
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
PHYSICS
SUGARS
TESTING
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Beschreibung
Zusammenfassung:A method is disclosed for derivatizing oligosaccharides to form synthetic N-linked glycoconjugates by converting a glycosylamine derivative of the oligosaccharide to a haloacetylated derivative as an intermediate compound prior to formation of the synthetic N-linked glycoconjugate to thereby maintain the beta -anomeric configuration of said N-linked glycoconjugate.