MEDICAL MATERIAL PERMITTING CELLS TO ENTER THEREINTO AND ARTIFICIAL SKIN

An improved medical material, penetrable by cells, which contains modified collagen being 0-80% of helical structure and a carrier (1) which has a higher resistance to enzymatic decomposition than the collagen. The modified collagen is a collagen from which the terminal part having an antigen is rem...

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Hauptverfasser: OHSAKI, KENICHI TERUMO KABUSHIKI KAISHA 2656-1, KATAKURA, TAKEO TERUMO KABUSHIKI KAISHA 2656-1, MORI, YUICHI, TATEBE, KEN TERUMO KABUSHIKI KAISHA 2656-1, KONISHI, JUN TERUMO KABUSHIKI KAISHA 2656-1, KOIDE, MIKIO TERUMO KABUSHIKI KAISHA 2656-1, OYAMADA, KAORU TERUMO KABUSHIKI KAISHA 2656-1, YOSHISATO, KATSUTOSHI
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:An improved medical material, penetrable by cells, which contains modified collagen being 0-80% of helical structure and a carrier (1) which has a higher resistance to enzymatic decomposition than the collagen. The modified collagen is a collagen from which the terminal part having an antigen is removed. The carrier (1) can be collagen, fibroin polylactic acid, muco polyglucose or alginic acid. It can also be a modified collagen from which the terminal part having an antigen is removed, or a collagen, having an introduced cross-linked structure or a fibrilised collagen with or without an introduced cross-linked structure. The medical material has the structure of a film, or a sponge with the carrier contained in the matrix. An artificial skin comprises, as a wound-contacting layer, this medical material in which fibrilised collagen in dispersed in the modified collagen which is in matrix condition, a supporting layer made of fibroin, and a water transmitting layer laminated on the other side of the supporting layer. An anti-bacterial agent is contained in at least one of the layers. Substance médicale dans laquelle les cellules peuvent pénétrer, contenant du collagène modifié comprenant de 0 à 80 % d'hélix et un support présentant une plus grande résistance contre la décomposition enzymatique que le collagène. On décrit également une peau artificielle utilisant cette substance comme couche de contact avec la plaie, ainsi qu'un procédé de production de cette peau artificielle.