Vaccines against septicemic bacteria

The bacteria expressing iron-regulated outer membrane proteins of which certain are siderophore or transferrin receptors can be used in a vaccinal preparation. Said bacteria are obtained from a culture in a medium in which the iron content is reduced to a level for obtaining an increased expression...

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Bibliographische Detailangaben
Hauptverfasser: BRUNEAU, PATRICK, AUDONNET, JEANRISTOPHE
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:The bacteria expressing iron-regulated outer membrane proteins of which certain are siderophore or transferrin receptors can be used in a vaccinal preparation. Said bacteria are obtained from a culture in a medium in which the iron content is reduced to a level for obtaining an increased expression of said proteins, and in particular of receptors, sufficient to induce, when said bacteria are used in a vaccine, the formation of antibodies preventing the specific recognition of siderophores by their receptors.