Cobalamine-acid hydrazides and cobalamine conjugates derived therefrom

The cobalamin acid hydrazides have the formula (I> B-CO-NH-NH-(R-CO-NH-NH)XH (I) in which B is the radical formed from cobalamins by elimination of a -CONH2 group, in particular the radical of cyanocobalamin, and R is a linking group (spacer), and x is 0 or 1. The cobalamin acid hydrazides of the...

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Bibliographische Detailangaben
Hauptverfasser:	HUBER, ERASMUS NAT, KLEIN, CHRISTIAN NAT, KUERZINGER, KONRAD NAT, DIECKHOFF, JOSEF NAT
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PHYSICS SUGARS TESTING
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Beschreibung
Zusammenfassung:	The cobalamin acid hydrazides have the formula (I> B-CO-NH-NH-(R-CO-NH-NH)XH (I) in which B is the radical formed from cobalamins by elimination of a -CONH2 group, in particular the radical of cyanocobalamin, and R is a linking group (spacer), and x is 0 or 1. The cobalamin acid hydrazides of the formula (I) can be used to prepare stable cobalamin conjugates of the formula (III> B-CO-NH-(NH-R-CO-NH)XN=GP (III> in which B, R and x have the abovementioned meaning, and GP is the radical of a glycosyl group-containing protein which is bonded via a glycosyl radical to the -NH-N= group. These cobalamin conjugates, for example the conjugate of the formula B12-d-CO-NH-NH-CO-CH2-(O-CH2-CH2)3-O-CH2-CO-NH-N = PODox, are very suitable for use in immunoassays, especially for the determination of cyanocobalamin.