Process for preparing dry crystals of alpha-L-aspartyl-L-phenylalanine methyl ester having improved solubility

In a process for preparing dry crystalline alpha -L-aspartyl-L-phenylalanine methyl ester having improved solubility (a) the crystallization of alpha -L-aspartyl-L-phenylalanine methyl ester is carried out without causing a forced liquid flow in the crystallization medium, (b) the formed crystals ar...

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Bibliographische Detailangaben
Hauptverfasser:	YASAKI, AKIHIKO, KISHIMOTO, SHINICHI, NARUSE, MASAYOSHI, OHURA, HARUTOSHI
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY FOODS OR FOODSTUFFS FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BYSUBCLASSES A23B - A23J HUMAN NECESSITIES METALLURGY ORGANIC CHEMISTRY PEPTIDES PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OFNUTRITIVE QUALITIES, PHYSICAL TREATMENT THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
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Zusammenfassung:	In a process for preparing dry crystalline alpha -L-aspartyl-L-phenylalanine methyl ester having improved solubility (a) the crystallization of alpha -L-aspartyl-L-phenylalanine methyl ester is carried out without causing a forced liquid flow in the crystallization medium, (b) the formed crystals are separated from the crystallization medium and subjected to a dewatering treatment to obtain wet crystals having a water content of not more than 50 wt.%, based on the overall weight of the wet crystals of alpha -L-aspartyl-L-phenylalanine methyl ester, and (c) the obtained wet crystals having a water content of not more than 50 wt.% are continuously air dried by a pneumatic conveyor dryer with hot air at 80 to 200 DEG C until the water content has reached 2 to 6 wt.%. r