Process for the production of 02,2'-anhydro-1-(beta-D-arabinofuranosyl)thymine

In the disclosed process, an O ,2 min anhydro-1-( beta -D-arabinofuranosyl)thymine is formed by condensing a 2-amino- beta -arabinofurano[1 min ,2 min :4,5,]-2-oxazoline with a compound of the formula wherein R1 is C1-C4 alkyl; X is halogen or OR2, wherein R2 is H, C1-C4 alkyl or phenyl; in the pres...

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Bibliographische Detailangaben
1. Verfasser:	MURTIASHAW, CHARLES WILLIAM
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	In the disclosed process, an O ,2 min anhydro-1-( beta -D-arabinofuranosyl)thymine is formed by condensing a 2-amino- beta -arabinofurano[1 min ,2 min :4,5,]-2-oxazoline with a compound of the formula wherein R1 is C1-C4 alkyl; X is halogen or OR2, wherein R2 is H, C1-C4 alkyl or phenyl; in the presence of a suitable solvent at about 0 DEG C to about 150 DEG C. Catalytic agents such as dimethylaminopyridine and triethylamine may also be added to accelerate the reaction. Protected intermediates of the anhydronucleosides and aminooxazolines are also disclosed.