New anthracycline derivatives and processes for the preparation of the same

New anthracycline derivatives and processes for the preparation of the same

As new anthracycline derivatives are now produced 7-O-(2,6-dideoxy-2-fluoro- alpha -L-mannopyranosyl)-daunomycinone and -adriamycinone, their 4-demethoxy derivatives and 14-O-ester derivatives of the adriamycinone compounds of them (I), as well as 4-demethoxy-7-O-(2,6-dideoxy-2-fluoro- alpha -L-talo...

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Bibliographische Detailangaben
Hauptverfasser: UMEZAWA, KAZUO, UMEZAWA, SUMIO, TSUCHIYA, TSUTOMU, MIYAKE, TOSHIAKI, TAKAGI, YASUSHI CI MANSION HIGASHI TOTSUKA, TAKEUCHI, TOMIO
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:As new anthracycline derivatives are now produced 7-O-(2,6-dideoxy-2-fluoro- alpha -L-mannopyranosyl)-daunomycinone and -adriamycinone, their 4-demethoxy derivatives and 14-O-ester derivatives of the adriamycinone compounds of them (I), as well as 4-demethoxy-7-O-(2,6-dideoxy-2-fluoro- alpha -L-talopyranosyl)-daunomycinone and -adriamycinone and 14-O-ester derivatives of the adriamycinone compound thereof (I') which exhibit excellent antitumor activities and are useful as antitumor agents. These new anthracycline derivatives may be produced by various processes.