HUMAN B LYMPHOTROPIC VIRUS (HBLV) ISOLATION AND PRODUCTS

A novel human B-lymphotropic virus (HBLV) associated with some malignancies in acquired immune deficiency syndrome (AIDS) and non-AIDS patients is isolated. The virus is detected in a patient suffering from AIDS by co-culturing sera from an AIDS patient with human B cells and examining for presence...

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Bibliographische Detailangaben
Hauptverfasser:	GALLO, ROBERT C, SALAHUDDIN, SYED ZAKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	A novel human B-lymphotropic virus (HBLV) associated with some malignancies in acquired immune deficiency syndrome (AIDS) and non-AIDS patients is isolated. The virus is detected in a patient suffering from AIDS by co-culturing sera from an AIDS patient with human B cells and examining for presence of the virus by sucrose gradient analysis or by Southern blot analysis of the virus genomic DNA. Analysis of virus infected cells can be carried out by producing large cytoplasmic infected cells and examining for membrane fluoresence. The virus is morphologically similar to viruses of the herpesvirus family but is readily distinguished from the known human and nonhuman primate herpesviruses by host range, in vitro biological effects, and antigenic features.