Cyclodextrin derivatives and processes for preparing same

Cyclodextrin derivatives and processes for preparing same

Partially methylated carboxyacyl-cyclodextrins of the general formula (I), wherein A means the cyclodextrin skeleton of the general formula (II) containing the substituents in the position labelled by the wavy line; W stands for an alkylene, alkenylene or arylene group or the substituted derivatives...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SZEJTLI, JOSEF, INSTITORIS, LASZLO, SZENTI, LAJOS, JODAL, ILDIKO, SZABO, TIBOR
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
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Beschreibung
Zusammenfassung:Partially methylated carboxyacyl-cyclodextrins of the general formula (I), wherein A means the cyclodextrin skeleton of the general formula (II) containing the substituents in the position labelled by the wavy line; W stands for an alkylene, alkenylene or arylene group or the substituted derivatives thereof; R means hydrogen, an alkyl, aryl or aralkyl group; m is 6, 7 or 8; n is an integer from 1 to 2m; and p is 2m-n+z, wherein the value of z is from 0 to 3 as well as their salts induce less haemolytic effect than the cyclodextrin compounds used as starting materials. They may be used to enhance the water solubility of pharmaceutically-active compounds.