LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS
This invention encompasses compounds of Formula I and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: X, Y, and Z are each independently O or S with S optionally oxidized to S = O; Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6...
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| creator | WEIER, RICHARD MATHIAS DEASON, JAMES RONALD STEALEY, MICHAEL ALLAN |
| description | This invention encompasses compounds of Formula I and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: X, Y, and Z are each independently O or S with S optionally oxidized to S = O; Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms; R1 is hydrogen or lower alkyl; n is 0 to 5; R2 is hydrogen, lower alkyl, cycloalkyl, -(CH2)n-CO2R1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; and Ar is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. This invention is in the field of pharmaceutical agents which act as leukotriene D4 (LTD4) antagonists and includes embodiments which act as leukotriene B4 (LTD4) antagonists. |
| format | Patent |
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This invention is in the field of pharmaceutical agents which act as leukotriene D4 (LTD4) antagonists and includes embodiments which act as leukotriene B4 (LTD4) antagonists.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1993</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930303&DB=EPODOC&CC=EP&NR=0308956B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19930303&DB=EPODOC&CC=EP&NR=0308956B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WEIER, RICHARD MATHIAS</creatorcontrib><creatorcontrib>DEASON, JAMES RONALD</creatorcontrib><creatorcontrib>STEALEY, MICHAEL ALLAN</creatorcontrib><title>LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS</title><description>This invention encompasses compounds of Formula I and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: X, Y, and Z are each independently O or S with S optionally oxidized to S = O; Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms; R1 is hydrogen or lower alkyl; n is 0 to 5; R2 is hydrogen, lower alkyl, cycloalkyl, -(CH2)n-CO2R1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; and Ar is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. This invention is in the field of pharmaceutical agents which act as leukotriene D4 (LTD4) antagonists and includes embodiments which act as leukotriene B4 (LTD4) antagonists.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1993</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD1cQ319g8J8nT1c1XwCXExUXD0cwEynECMEEd3fz_P4JBgHgbWtMSc4lReKM3NoODmGuLsoZtakB-fWlyQmJyal1oS7xpgYGxgYWlq5mRoTIQSAE7cIsc</recordid><startdate>19930303</startdate><enddate>19930303</enddate><creator>WEIER, RICHARD MATHIAS</creator><creator>DEASON, JAMES RONALD</creator><creator>STEALEY, MICHAEL ALLAN</creator><scope>EVB</scope></search><sort><creationdate>19930303</creationdate><title>LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS</title><author>WEIER, RICHARD MATHIAS ; DEASON, JAMES RONALD ; STEALEY, MICHAEL ALLAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0308956B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1993</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WEIER, RICHARD MATHIAS</creatorcontrib><creatorcontrib>DEASON, JAMES RONALD</creatorcontrib><creatorcontrib>STEALEY, MICHAEL ALLAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WEIER, RICHARD MATHIAS</au><au>DEASON, JAMES RONALD</au><au>STEALEY, MICHAEL ALLAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS</title><date>1993-03-03</date><risdate>1993</risdate><abstract>This invention encompasses compounds of Formula I and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: X, Y, and Z are each independently O or S with S optionally oxidized to S = O; Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms; R1 is hydrogen or lower alkyl; n is 0 to 5; R2 is hydrogen, lower alkyl, cycloalkyl, -(CH2)n-CO2R1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; and Ar is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. This invention is in the field of pharmaceutical agents which act as leukotriene D4 (LTD4) antagonists and includes embodiments which act as leukotriene B4 (LTD4) antagonists.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS |
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