LEUKOTRIENE LTD4 AND LTB4 ANTAGONISTS

This invention encompasses compounds of Formula I and the pharmaceutically acceptable salts and geometrical and optical isomers thereof wherein: X, Y, and Z are each independently O or S with S optionally oxidized to S = O; Alk is straight or branched chain alkylene or hydroxyalkylene containing 1-6 carbon atoms; R1 is hydrogen or lower alkyl; n is 0 to 5; R2 is hydrogen, lower alkyl, cycloalkyl, -(CH2)n-CO2R1, phenyl, phenyl substituted with halo, lower alkyl or lower alkoxy; and Ar is 5,6,7,8-tetrahydro-1-naphthalenyl, phenyl, or phenyl substituted with lower alkyl, hydroxy, lower alkoxy, or lower alkanoyl. This invention is in the field of pharmaceutical agents which act as leukotriene D4 (LTD4) antagonists and includes embodiments which act as leukotriene B4 (LTD4) antagonists.