POLYMER-COATED OPTICAL STRUCTURES

PCT No. PCT/GB88/00177 Sec. 371 Date Nov. 4, 1988 Sec. 102(e) Date Nov. 4, 1988 PCT Filed Mar. 9, 1988 PCT Pub. No. WO88/07203 PCT Pub. Date Sep. 22, 1988.A method is disclosed for coating the surface of an optical structure, such as a diffraction grating, useful for the detection of a ligand, which...

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Hauptverfasser:	SAWYERS, CRAIG GEORGE, DRAKE, ROSEMARY ANN LUCY
Format:	Patent
Sprache:	eng
Schlagworte:	INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES LAYERED PRODUCTS LAYERED PRODUCTS, i.e. PRODUCTS BUILT-UP OF STRATA OF FLAT ORNON-FLAT, e.g. CELLULAR OR HONEYCOMB, FORM MEASURING OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS OPTICS PERFORMING OPERATIONS PHYSICS TESTING TRANSPORTING
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Zusammenfassung:	PCT No. PCT/GB88/00177 Sec. 371 Date Nov. 4, 1988 Sec. 102(e) Date Nov. 4, 1988 PCT Filed Mar. 9, 1988 PCT Pub. No. WO88/07203 PCT Pub. Date Sep. 22, 1988.A method is disclosed for coating the surface of an optical structure, such as a diffraction grating, useful for the detection of a ligand, which method comprises forming on the surface of the optical structure a thin, uniform layer of a polymerizable material, particularly one which polymerizes on exposure to light or heat, and subsequently exposing said material to polymerizing conditions. A specific binding partner is subsequently absorbed on or bound to the cured polymer layer, either directly or indirectly. Complex formation between the specific binding partner and ligand present in the sample to be analyzed alters the optical properties of the device and the change forms the basis of an assay.