Nonglycosylated plasminogen activator and method of preparation

Novel, structurally modified plasminogen activators are provided which are incapable of receiving N-linked carbohydrate residues. The amino acid modified forms of the plasminogen activators retain their specific plasminogen activator activity and, thus, continue to function to activate plasminogen i...

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Bibliographische Detailangaben
Hauptverfasser:	MOIR, DONALD T, BALTIMORE, DAVID, BROEZE, ROBERT J
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Novel, structurally modified plasminogen activators are provided which are incapable of receiving N-linked carbohydrate residues. The amino acid modified forms of the plasminogen activators retain their specific plasminogen activator activity and, thus, continue to function to activate plasminogen in initiating blood clot lysis.