PARATHYROID HORMONE ANTAGONISTS

The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone which comprises PTH(1-34)NH2, [Tyr ]PTH (1-34)NH2, [Nle , Tyr ]PTH(1-34(1-34)NH2; PTH(3-34)NH2,[Tyr ]PTH(3-34)NH2, [Nle , Tyr ]PTH(3-34)NH2; PTH(4-34)NH2, [Ty...

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Bibliographische Detailangaben
Hauptverfasser:	CAPORALE, LYNN H, NUTT, RUTH F, VEBER, DANIEL F, LEVY, JAY J, ROSENBLATT, MICHAEL
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to the use of peptide hormone analogues as inhibitors of their respective naturally occurring peptide hormone which comprises PTH(1-34)NH2, [Tyr ]PTH (1-34)NH2, [Nle , Tyr ]PTH(1-34(1-34)NH2; PTH(3-34)NH2,[Tyr ]PTH(3-34)NH2, [Nle , Tyr ]PTH(3-34)NH2; PTH(4-34)NH2, [Tyr ]PTH(4-34)NH2, [Nle ,Tyr ] PTH(4-34)NH2; PTH(5-34)NH2,[Tyr ]PTH (5-34)NH2, [Nle ,Tyr ]PTH(5-34)NH2; PTH(7-34)NH2, [Tyr ]PTH(7-34)NH2, [Nle , Tyr ]PTH(7-34)NH2 and wherein Gly is substituted by an amino acid selected from the group consisting of L-Pro, D-Pro, L-Ala, D-Ala, Aib and NMeGly.