PIPERIDINE COMPOUNDS AND PHARMACEUTICAL USES THEREOF

Piperidine compounds of the formula: or isomers thereof as well as pharmaceutically acceptable salt and/or hydrate forms thereof, and piperidine compounds of the formula: or isomers thereof as well as salt and/or hydrate forms thereof. In the above formulae, A represents a methylene group, an oxygen...

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Bibliographische Detailangaben
Hauptverfasser:	YAOKA, OSAMU, HAKAMADA, ICHIRO, IKEBE, TSUGUO, MURAKAMI, SHU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Piperidine compounds of the formula: or isomers thereof as well as pharmaceutically acceptable salt and/or hydrate forms thereof, and piperidine compounds of the formula: or isomers thereof as well as salt and/or hydrate forms thereof. In the above formulae, A represents a methylene group, an oxygen atom or a sulfur atom; B represents an oxygen atom or a sulfur atom; R and R independently represent a hydrogen atom, a lower alkyl group or an aralkyl group; R represents a hydrogen atom or an amino protecting group; Z represents an amino group or a protected amino group, a hydroxy group, or a reactive atom or group; m represents 1 or 2; and n represents the integer of 0 to 3. Piperidine compounds (I) possess an inhibitory activity against angiotensin-converting enzyme, and exhibit a long lasting hypotensive activity and are useful as anti-hypertensive agents. Piperidine compounds (II) are useful as intermediates for said piperidine compounds (I).