CHROMOGENE COMPOUNDS, THEIR MANUFACTURE AND USE AS ENZYME SUBSTRATES

Compounds of the formula II in which R represents an amino acid radical or the radical of an oligopeptide in which amino groups are optionally substituted by protective groups, R and R are identical or different and denote hydrogen, or a lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl or a...

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Bibliographische Detailangaben
Hauptverfasser: WIELINGER, HANSPHIL, ZIMMERMANN, GERD NAT
Format: Patent
Sprache:eng ; ger
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Beschreibung
Zusammenfassung:Compounds of the formula II in which R represents an amino acid radical or the radical of an oligopeptide in which amino groups are optionally substituted by protective groups, R and R are identical or different and denote hydrogen, or a lower alkyl, lower alkoxy, carboxyl, lower alkoxycarbonyl or an optionally lower alkyl-substituted carboxamido group or, if R and R are adjacent, represent a -CH=CH-CH=CH- group, Z denotes a cross-conjugated positively charged bicyclic heterocyclic system and X denotes an anion of an organic or inorganic acid. These compounds are particularly suitable as chromogenic substrates for determining the activity of enzymes which cleave peptide bonds.