SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)

SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)

A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KARA, URSULA, ANNA, KATE, STENZEL, DEBORAH, JOAN, SAUL, ALLAN, JAMES, GEYSEN, HENDRIK, MARIO, BUSHELL, GILLIAN, ROBIN
Format: Patent
Sprache:eng ; fre ; ger
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROCESSES USING MICROORGANISMS
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.