New aralkyl-1,4-dihydropyridines, a method for their preparation and pharmaceutical compositions containing them

1,4-Dihydropyridines of formula I: wherein: - X is a -CO2R1, cyano, nitro, -COCH3 group; - R and R1, that can be the same or different, are a primary, secondary or tertiary, saturated or unsaturated, linear or branched C1-C6 alkyl group that can be substituted or not by one or more hydroxy, C1-C7-mo...

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Bibliographische Detailangaben
Hauptverfasser:	TOGNELLA, SERGIO, ZALIANI, ANDREA, FRIGERIO, MARCO, GANDOLFI, CARMELO A, GERMINI, MAURO, TOFANETTI, ODOARDO
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	1,4-Dihydropyridines of formula I: wherein: - X is a -CO2R1, cyano, nitro, -COCH3 group; - R and R1, that can be the same or different, are a primary, secondary or tertiary, saturated or unsaturated, linear or branched C1-C6 alkyl group that can be substituted or not by one or more hydroxy, C1-C7-monoalkylamino, di-C1-C7-alkylamino, benzylamino, C1-C6-alkoxy, phenoxy groups optionally substituted by one or more C1-C6 alkyl, C1-C6 alkoxy, halo-C1-C6 alkyl, halo-C1-C6-alkoxy, halogen, nitro, cyano, C1-C6 alkoxycarbonyl, C1-C6 alkylthio, NHCOR5, SO2R6, C1-C4-alkylamino , di(C1-C4)alkylamino, hydroxy. - R2 is hydrogen; - R3 is hydrogen or a hydroxy, -OCOR5, OSO2R6, azide, amino, -NHPO(OR7)2, -NHCOR5 group, a C1-C4-alkoxy group or a fluorine, chlorine, bromine or iodine atom, a SH group, a SCOR6 or a C1-C6-alkylthio, phenylthio or benzylthio group; - R4 is an optionally substituted aromatic or an optionally substituted 5- or 6-membered heteroaromatic group, containing one or more heteroatoms selected in the group of N,S,O, wherein the substituent is selected from one or more hydroxy, C1-C7-monoalkylamino, di-C1-C7-alkylamino, benzylamino, C1-C6-alkoxy, phenoxy groups optionally substituted by one or more C1-C6 alkyl, C1-C6 alkoxy, halo-C1-C6 alkyl, halo-C1-C6-alkoxy, halogen, nitro, cyano, C1-C6 alkoxycarbonyl, C1-C6 alkylthio, NHCOR5, SO2R6, C1-C4-alkylamino , di(C1-C4)alkylamino, hydroxy; - Y is one or more substituents, that can be the same or different, selected in the group of C1-C4-alkoxy, halogen, nitro, cyano, C1-C6-alkoxycarbonyl, C1-C6-alkylthio, halo-C1-C6-alkyl, halo-C1-C6-alkoxy, NHCOR5 or NHSO2R6; - R5 is hydrogen or a C1-C4-alkyl, trihalomethyl, C1-C4-alkoxy or phenyl group, optionally substituted by one or more nitro, halogen, C1-C4 alkyl, C1-C4-alkoxy, amino groups; - R6is hydrogen or a C1-C4-alkyl, trihalomethyl, phenyl or p-methylphenyl group; - R7 is a C1-C4-alkyl group or a phenyl group; are useful as antihypertensive, cytoprotecting or anti-ulcer agents.