Polysubstituted aryl acridinium esters

The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immun...

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Bibliographische Detailangaben
Hauptverfasser:	CHANG, STEVE C.S, PALMACCI, STEPHEN A, LAW, SAY-JONG, CUBICCIOTTI, ROGER S
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	ADHESIVES CHEMISTRY DYES GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FORELSEWHERE MEASURING METALLURGY MISCELLANEOUS APPLICATIONS OF MATERIALS MISCELLANEOUS COMPOSITIONS NATURAL RESINS ORGANIC CHEMISTRY PAINTS PHYSICS POLISHES TECHNICAL SUBJECTS COVERED BY FORMER USPC TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS TESTING
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Beschreibung
Zusammenfassung:	The present invention relates to novel acridinium esters which are useful as luminescent labels in specific binding assays such as immunoassays or nucleic acid hybridization assays. More particularly, polysubstituted aryl acridinium esters are highly stable labels for use in a chemiluminescent immunoassay. More particularly; there is disclosed a luminescent compound comprising a polysubstituted aryl acridiniun ester selected from the group having the following structure: where R1 is an alkyl, alkenyl,alkynyl, or aryl group; R2, R3, R5, or R7 are a hydrogen, amino, carboxyl, hydroxyl, alkoxyl, nitro, or halide group; R4 or R8 are an alkyl, alkenyl, alkynyl, aryl, alkoxyl,amino, amido, sulfonamido, or sulfide group; R6 represents the following substituent: R6 = -R9 - R10 where R9 is not required but optionally can be an alkyl, aryl, or aralkyl group, and R10 is selected from the following: ; X is CH3SO4; OSO2F; a halide; OSO2CF3; OSO2C4F9; R is alkyl, aryl, aralkyl, and finally R5, R6, and R7 substituent positions on the phenoxy ring are interchangeable.