STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF INDOLE DERIVATIVES

STEREOSPECIFIC PROCESS FOR THE SYNTHESIS OF INDOLE DERIVATIVES

The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: (I) which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is co...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: NISATO, DINO, TONNERRE, BERNARD, PLOUZANE, CLAUDE, WAGNON, JEAN LE HAMEAU DE LA RAUZE
Format: Patent
Sprache:eng ; fre
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: (I) which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).