METHODS FOR PREPARING HYDROXY COMPOUNDS AND INTERMEDIATES
A method for preparing an unprotected hydroxy compound from a protected hydroxy compound of the general formula I in which R1 is the non-hydroxy moiety of the protected hydroxy compound; R2, R3, R4 and R5 which may be the same or different are hydrogen, C1-4 alkyl or aryl; and R6, R7 and R8 which ma...
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Zusammenfassung: | A method for preparing an unprotected hydroxy compound from a protected hydroxy compound of the general formula I in which R1 is the non-hydroxy moiety of the protected hydroxy compound; R2, R3, R4 and R5 which may be the same or different are hydrogen, C1-4 alkyl or aryl; and R6, R7 and R8 which may be same or different are C1-4 alkyl, optionally substituted phenyl or a carrier in which the compound of formula I is reacted with a Lewis acid followed by reaction with water forming a hydroxy compound of the general formula II R1-OH II; A method for preparing a compound of the general formula III R1-O-A III in which R1 is the non-hydroxy moiety of a hydroxy compound; and A is an acyl group; A compound of the general formula IV R1-O-X IV in which R1 is the non-hydroxy moiety of a hydroxy compound; and X is a residue of a Lewis acid; A method according to claim 4 in which R1 is the non-hydroxy moiety of a hydroxy-containing amino acid forming part of a peptide, and one of R6, R7 and R8 is a carrier; and A compound of the general formula Ia wherein R1 is a carbohydrate moiety containing two or more sugar units or a derivative thereof. |
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