Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use
Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten. 1. Claims for the Contracting States : BE, CH,...
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creator | SCHMIED, BERNHARD RUEBSAMEN, KLAUS BALDINGER, VERENA TRAUT, MARTIN GRIES, JOSEF GEISS, KARL-HEINZ LEHMANN, HANS DIETER, DR KROPP, RUDOLF |
description | Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten.
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A substituted pyrrol-1-ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P9,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl. 1. Claim for the Contracting States : AS, ES A process for the preparation of a substituted pyrrol-1- ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P10,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 , R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl, wherein a p-aminophenyldihydropyridazinone of the formula II see diagramm : EP0231744,P11,F1 where R**1 , R**2 , R**6 , A and B have the meanings described for formula I, is reacted with a tetrahydrofuran of the formula III see diagramm : EP0231744,P11,F2 where R**3 , R**4 and R**5 have the meanings stated in formula I, R**5 is bonded to ring atom 4 or 5 of the tetrahydrofuran ring and R**7 is C1 -C4 -alkoxy, C1 -C4 -alkanoyloxy, chlorine or bromine, and, if required, the compound thus obtained is hydrogenated at the C=O group or reacted with an organometallic compound F-Met, where F |
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fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0231744A1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0231744A1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0231744A13</originalsourceid><addsrcrecordid>eNqNyjEKAjEQQNFtLES9Qw5gwLgL1ousWFgI2i-jGclAmAzJpIin18IDWH14_GV3udVHUdKq6I20nFO0zrYoAblFT6H5nL5OHt7EibFsjQakbCSjQAalxAbYm1pw3S1eEAtufl115jTdj2eLkmYsAk9k1Hm67va9OwzD6Po_lg_c1Dac</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use</title><source>esp@cenet</source><creator>SCHMIED, BERNHARD ; RUEBSAMEN, KLAUS ; BALDINGER, VERENA ; TRAUT, MARTIN ; GRIES, JOSEF ; GEISS, KARL-HEINZ ; LEHMANN, HANS DIETER, DR ; KROPP, RUDOLF</creator><creatorcontrib>SCHMIED, BERNHARD ; RUEBSAMEN, KLAUS ; BALDINGER, VERENA ; TRAUT, MARTIN ; GRIES, JOSEF ; GEISS, KARL-HEINZ ; LEHMANN, HANS DIETER, DR ; KROPP, RUDOLF</creatorcontrib><description>Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten.
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A substituted pyrrol-1-ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P9,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl. 1. Claim for the Contracting States : AS, ES A process for the preparation of a substituted pyrrol-1- ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P10,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 , R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl, wherein a p-aminophenyldihydropyridazinone of the formula II see diagramm : EP0231744,P11,F1 where R**1 , R**2 , R**6 , A and B have the meanings described for formula I, is reacted with a tetrahydrofuran of the formula III see diagramm : EP0231744,P11,F2 where R**3 , R**4 and R**5 have the meanings stated in formula I, R**5 is bonded to ring atom 4 or 5 of the tetrahydrofuran ring and R**7 is C1 -C4 -alkoxy, C1 -C4 -alkanoyloxy, chlorine or bromine, and, if required, the compound thus obtained is hydrogenated at the C=O group or reacted with an organometallic compound F-Met, where F is C1 -C6 -alkyl or phenyl and Met is an alkali metal atom or a radical MgX, in which X is chlorine, bromine or iodine.</description><edition>4</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1987</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870812&DB=EPODOC&CC=EP&NR=0231744A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19870812&DB=EPODOC&CC=EP&NR=0231744A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHMIED, BERNHARD</creatorcontrib><creatorcontrib>RUEBSAMEN, KLAUS</creatorcontrib><creatorcontrib>BALDINGER, VERENA</creatorcontrib><creatorcontrib>TRAUT, MARTIN</creatorcontrib><creatorcontrib>GRIES, JOSEF</creatorcontrib><creatorcontrib>GEISS, KARL-HEINZ</creatorcontrib><creatorcontrib>LEHMANN, HANS DIETER, DR</creatorcontrib><creatorcontrib>KROPP, RUDOLF</creatorcontrib><title>Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use</title><description>Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten.
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A substituted pyrrol-1-ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P9,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl. 1. Claim for the Contracting States : AS, ES A process for the preparation of a substituted pyrrol-1- ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P10,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 , R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl, wherein a p-aminophenyldihydropyridazinone of the formula II see diagramm : EP0231744,P11,F1 where R**1 , R**2 , R**6 , A and B have the meanings described for formula I, is reacted with a tetrahydrofuran of the formula III see diagramm : EP0231744,P11,F2 where R**3 , R**4 and R**5 have the meanings stated in formula I, R**5 is bonded to ring atom 4 or 5 of the tetrahydrofuran ring and R**7 is C1 -C4 -alkoxy, C1 -C4 -alkanoyloxy, chlorine or bromine, and, if required, the compound thus obtained is hydrogenated at the C=O group or reacted with an organometallic compound F-Met, where F is C1 -C6 -alkyl or phenyl and Met is an alkali metal atom or a radical MgX, in which X is chlorine, bromine or iodine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1987</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNyjEKAjEQQNFtLES9Qw5gwLgL1ousWFgI2i-jGclAmAzJpIin18IDWH14_GV3udVHUdKq6I20nFO0zrYoAblFT6H5nL5OHt7EibFsjQakbCSjQAalxAbYm1pw3S1eEAtufl115jTdj2eLkmYsAk9k1Hm67va9OwzD6Po_lg_c1Dac</recordid><startdate>19870812</startdate><enddate>19870812</enddate><creator>SCHMIED, BERNHARD</creator><creator>RUEBSAMEN, KLAUS</creator><creator>BALDINGER, VERENA</creator><creator>TRAUT, MARTIN</creator><creator>GRIES, JOSEF</creator><creator>GEISS, KARL-HEINZ</creator><creator>LEHMANN, HANS DIETER, DR</creator><creator>KROPP, RUDOLF</creator><scope>EVB</scope></search><sort><creationdate>19870812</creationdate><title>Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use</title><author>SCHMIED, BERNHARD ; RUEBSAMEN, KLAUS ; BALDINGER, VERENA ; TRAUT, MARTIN ; GRIES, JOSEF ; GEISS, KARL-HEINZ ; LEHMANN, HANS DIETER, DR ; KROPP, RUDOLF</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0231744A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1987</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHMIED, BERNHARD</creatorcontrib><creatorcontrib>RUEBSAMEN, KLAUS</creatorcontrib><creatorcontrib>BALDINGER, VERENA</creatorcontrib><creatorcontrib>TRAUT, MARTIN</creatorcontrib><creatorcontrib>GRIES, JOSEF</creatorcontrib><creatorcontrib>GEISS, KARL-HEINZ</creatorcontrib><creatorcontrib>LEHMANN, HANS DIETER, DR</creatorcontrib><creatorcontrib>KROPP, RUDOLF</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHMIED, BERNHARD</au><au>RUEBSAMEN, KLAUS</au><au>BALDINGER, VERENA</au><au>TRAUT, MARTIN</au><au>GRIES, JOSEF</au><au>GEISS, KARL-HEINZ</au><au>LEHMANN, HANS DIETER, DR</au><au>KROPP, RUDOLF</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use</title><date>1987-08-12</date><risdate>1987</risdate><abstract>Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten.
1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A substituted pyrrol-1-ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P9,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl. 1. Claim for the Contracting States : AS, ES A process for the preparation of a substituted pyrrol-1- ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P10,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 , R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl, wherein a p-aminophenyldihydropyridazinone of the formula II see diagramm : EP0231744,P11,F1 where R**1 , R**2 , R**6 , A and B have the meanings described for formula I, is reacted with a tetrahydrofuran of the formula III see diagramm : EP0231744,P11,F2 where R**3 , R**4 and R**5 have the meanings stated in formula I, R**5 is bonded to ring atom 4 or 5 of the tetrahydrofuran ring and R**7 is C1 -C4 -alkoxy, C1 -C4 -alkanoyloxy, chlorine or bromine, and, if required, the compound thus obtained is hydrogenated at the C=O group or reacted with an organometallic compound F-Met, where F is C1 -C6 -alkyl or phenyl and Met is an alkali metal atom or a radical MgX, in which X is chlorine, bromine or iodine.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use |
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