Substituted pyrrol-1-ylphenyldihydropyridazinones, their preparation and use

Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten. 1. Claims for the Contracting States : BE, CH,...

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Hauptverfasser: SCHMIED, BERNHARD, RUEBSAMEN, KLAUS, BALDINGER, VERENA, TRAUT, MARTIN, GRIES, JOSEF, GEISS, KARL-HEINZ, LEHMANN, HANS DIETER, DR, KROPP, RUDOLF
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Sprache:eng ; fre ; ger
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Zusammenfassung:Es werden substituierte Pyrrol-1-ylphenyldihydropyridazinone der Formel worin A, B, D, E und R¹ - R die in der Beschreibung angegebene Bedeutung besitzen, sowie deren Herstellung beschrieben. Die Verbindungen eignen sich zur Bekämpfung von Krankheiten. 1. Claims for the Contracting States : BE, CH, DE, FR, GB, IT, LI, NL, SE A substituted pyrrol-1-ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P9,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl. 1. Claim for the Contracting States : AS, ES A process for the preparation of a substituted pyrrol-1- ylphenyldihydropyridazinone of the formula I see diagramm : EP0231744,P10,F3 where R**1 is hydrogen, methyl or hydroxymethyl, R**2 is hydrogen or methyl, or R**1 and R**2 together form a radical -(CH2 )m -, in which m is an integer from 1 to 4, R**3 , R**4 and R**5 independently of one another are each hydrogen or C1 -C6 -alkyl, R**6 is hydrogen or, together with R**1 , forms a radical -(CH2 )n -, in which n is 1, 2 or 3, or the radical -CH=CH-, A and B are each hydrogen or together form a bond, D is hydrogen, C1 -C6 -alkyl or phenyl, and E is hydrogen, or D and E together form a bond, with the proviso that, if R**3 is hydrogen, one or both of the radicals R**4 and R**5 are C1 -C6 -alkyl or D is C1 -C6 -alkyl or phenyl, wherein a p-aminophenyldihydropyridazinone of the formula II see diagramm : EP0231744,P11,F1 where R**1 , R**2 , R**6 , A and B have the meanings described for formula I, is reacted with a tetrahydrofuran of the formula III see diagramm : EP0231744,P11,F2 where R**3 , R**4 and R**5 have the meanings stated in formula I, R**5 is bonded to ring atom 4 or 5 of the tetrahydrofuran ring and R**7 is C1 -C4 -alkoxy, C1 -C4 -alkanoyloxy, chlorine or bromine, and, if required, the compound thus obtained is hydrogenated at the C=O group or reacted with an organometallic compound F-Met, where F