3-Amino-4,5-dihydroxypiperidines, process for their preparation and their use

Die Erfindung betrifft 3-Amino-4,5-dihydroxypiperidine der allgemeinen Formel (I) in welcher R¹, R² und R³ die in der Beschreibung angegebenen Bedeutungen haben, Verfahren zu ihrer Herstellung und ihre Verwendung in Arzneimitteln, insbesondere zur Beeinflussung des Lipid- und Kohlehydratstoffwechsels. A 3-amino-4,5-dihydroxy-piperidine compound of the formula (I) (I) in which R1 represents hydrogen, alkyl having up to 8 carbon atoms, aralkyl having 7 to 14 carbon atoms, or represents a group of the formula R4 denotes straight-chain or branched alkyl having up to 8 carbon atoms, straight-chain or branched alkoxy having up to 8 carbon atoms, or aralkoxy having up to 10 carbon atoms, and R2 and R3 represent hydrogen or represent the group NHR5, R5 having the same meaning as R1 and being identical to or different from the latter, with the proviso that, in every case, one substituent of R2 or R3 represents hydrogen and the other substituent of R2 or R3 represents NHR5, and physiologically acceptable salts thereof. Such compound is useful to treat prediabetes, gastritis, constipation, caries, atherosclerosis, obesity, diabetes and hyperlipoproteinaemia.