PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED 5-NITROSO-4,6-DIAMINO-PYRIMIDINES

PROCESS FOR THE PREPARATION OF 4-SUBSTITUTED 5-NITROSO-4,6-DIAMINO-PYRIMIDINES

The 2-substituted 5-nitroso-4,6-diamino-pyrimidines are prepared by nitrosating malonitrile and an amidine in the presence of a nitrite salt to give the corresponding amidine salt of isonitroso-malonitrile, which is then converted to the final product in the presence of an aprotic polar solvent in a...

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Bibliographische Detailangaben
1. Verfasser: O'MURCHU, COLM
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The 2-substituted 5-nitroso-4,6-diamino-pyrimidines are prepared by nitrosating malonitrile and an amidine in the presence of a nitrite salt to give the corresponding amidine salt of isonitroso-malonitrile, which is then converted to the final product in the presence of an aprotic polar solvent in a basic medium by a heat treatment.