ANTIGEN DETERMINANT PEPTIDES AND A PROCESS FOR THE PREPARATION THEREOF

Antigen determinant peptides of the general formula I H - Val - X - Y (I) in which X represents an octapeptidic to undecapeptidic sequence of a defined structure Tyr-Tyr-Arg-Asp-Ser-Arg-Asn-Pro-Leu, Phe-Ile-His-Asn-Phe-Lys-Arg-Lys-Gly, Val-Pro-Arg-Arg-Lys-Ala-Lys-Ile, Leu-His-Thr-Gly-Glu-Arg-Asp-Trp-His-Leu-Gly, Ser-Gly-Lys-Ala-Arg-Gly-Trp-Phe or Ser-Ile-Glu-Trp-Arg-Lys-Lys-Arg-Tyr-Ser and Y stands for a hydroxyl or an amino group, available by fragment synthesis or successive condensation of the respective amino acid residues (stepwise build-up) in solution or on a solid carrier, are expected to be of use as diagnostic agents for the so-called acquired immunodeficiency syndrome (AIDS), and also to have a potential as monodeterminant antibodies and safe synthetic vaccine agents combating the human T-cell lymphotropic type III virus (HTLV-III, HIV).