4-CYANOPIPERIDINE DERIVATIVES, PREPARATION AND USE THEREOF

4-CYANOPIPERIDINE DERIVATIVES, PREPARATION AND USE THEREOF

A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I):wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agen...

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Hauptverfasser: YAMAUCHI, HIROSHI, TAKAYANAGI, KEIZO, KOIWA, ATSUSHI, KOMATU, YUUKI, NOMOTO, SEIICHIRO, TANAKA, YASUHIDE, KANAI, TAKEO, ENDOH, SHINICHI, SUGIYAMA, ISAO
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:A novel 4-cyanopiperidine derivative, which is represented by the following general formula (I):wherein X means a halogen atom, or an acid addition salt thereof, is prepared by reacting N-(2-hydroxyethyl)-4-carbamoylpiperidine or an acid addition salt thereof with a dehydrating and halogenating agent; or by reacting 4-cyanopiperidine or a salt thereof with a compound represented by the following general formula (IV):wherein X has the same meaning as defined above and Y denotes the same halogen atom as X or another halogen atom. The derivative is useful as intermediate for synthesis of quinuclidine derivative which is in turn useful as intermediate for the production of medicines, chemicals etc.