HIRUDIN-PA AND DERIVATIVES THEREOF, PROCESS FOR THE PRODUCTION A ND UTILIZATION THEREOF

PCT No. PCT/EP85/00701 Sec. 371 Date Aug. 6, 1986 Sec. 102(e) Date Aug. 6, 1986 PCT Filed Dec. 12, 1985 PCT Pub. No. WO86/03493 PCT Pub. Date Jun. 19, 1986.The present invention relates to a new content substance found in leeches (Hirudo medicinalis), the derivatives of this abbreviated at the N-ter...

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Hauptverfasser:	SEEMULLER, URSULA, DODT, JOHANNES, FRITZ, HANS, FINK, ERNST
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Zusammenfassung:	PCT No. PCT/EP85/00701 Sec. 371 Date Aug. 6, 1986 Sec. 102(e) Date Aug. 6, 1986 PCT Filed Dec. 12, 1985 PCT Pub. No. WO86/03493 PCT Pub. Date Jun. 19, 1986.The present invention relates to a new content substance found in leeches (Hirudo medicinalis), the derivatives of this abbreviated at the N-terminus and the C-terminus, and the desulfated derivatives therefrom as well as a process for the production of these compounds, and their use. These compounds possess thrombin-inhibiting properties and can be used to inhibit clotting in human and animals, for blood conservation, or as reagents for the analytical determination of thrombin.