2-SUBSTITUTED QUINOLINES, THEIR PREPARATION AND USE

Compounds having the formula: are selective antagonists of leukotrienes of D4. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents and may be made up into pharmaceutical compositions. In the formula R is H, halogen, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, -OR , -SR , -NR R , -CHO, -COOR , -(C=0)R , -C(OH)R R , -CN, -NO2, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, substituted or unsubstituted phenyl, substituted or unsubstituted benzyl, or substituted or unsubstituted phenethyl; R is -(A)m-(CR =CR )p-(CR R )m-Q; R is H, halogen, -NO2, -CN, -OR , -SR , NR R , or C1-C8 alkyl; R is H or C1-C4 alkyl; R is A) a monocyclic or bicyclic heterocyclic radical containing from 3 to 12 nuclear carbon atoms and 1 or 2 nuclear heteroatoms selected from N and S with at least one being N, and with each ring in the heterocyclic radical being formed of 5 or 6 atoms, or B) the radical W-R ; R contains up to 21 carbon atoms and is (1) a hydrocarbon radical or (2) an acyl radical of an organic acyclic or monocyclic carboxylic acid containing not more than 1 heteroatom in the ring; R is -OR , -SR , or NR R ; R is H, C1-C6 alkyl, -(C=O)R , unsubstituted phenyl or unsubstituted benzyl; R is H, C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, -CF3, or unsubstituted phenyl, benzyl, or phenethyl; m is 0-8; n is 1 or 2;