7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydr...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: GALAMBOS, GEZA, PAPP, GYULA, HADHAZY, PAL, KANAI, KAROLY, UDVARY, EVA, MARTON, JENO, KOVACS, GABOR, GYORY, PETER, TOMOSKOZI, ISTVAN, SZEKERES, LASZLO, KORMOCZY, PETER, STADLER, ISTVAN, DORMAN, GYORGY
Format: Patent
Sprache:eng ; ger
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue
container_start_page
container_title
container_volume
creator GALAMBOS, GEZA
PAPP, GYULA
HADHAZY, PAL
KANAI, KAROLY
UDVARY, EVA
MARTON, JENO
KOVACS, GABOR
GYORY, PETER
TOMOSKOZI, ISTVAN
SZEKERES, LASZLO
KORMOCZY, PETER
STADLER, ISTVAN
DORMAN, GYORGY
description The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.
format Patent
fullrecord <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0205969A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0205969A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0205969A33</originalsourceid><addsrcrecordid>eNqNi0EKwjAQRbtxIeod5gAGSotKl0M6NgNtMiQpuJFSJK5EC_X-aMEDuPo83vvr7HpS7uKUNFwoEkO1Z0sQsI1hD9EQexBPgh4jOwtoaxCDvkNNfWSNLWjXiQu86PAFG5Et22Y5d9tsdR8fc9r9dpPBmaI2Kk2vIc3TeEvP9B5I8iI_VMcKy_KP5AN_MjJR</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM</title><source>esp@cenet</source><creator>GALAMBOS, GEZA ; PAPP, GYULA ; HADHAZY, PAL ; KANAI, KAROLY ; UDVARY, EVA ; MARTON, JENO ; KOVACS, GABOR ; GYORY, PETER ; TOMOSKOZI, ISTVAN ; SZEKERES, LASZLO ; KORMOCZY, PETER ; STADLER, ISTVAN ; DORMAN, GYORGY</creator><creatorcontrib>GALAMBOS, GEZA ; PAPP, GYULA ; HADHAZY, PAL ; KANAI, KAROLY ; UDVARY, EVA ; MARTON, JENO ; KOVACS, GABOR ; GYORY, PETER ; TOMOSKOZI, ISTVAN ; SZEKERES, LASZLO ; KORMOCZY, PETER ; STADLER, ISTVAN ; DORMAN, GYORGY</creatorcontrib><description>The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.</description><edition>4</edition><language>eng ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19890419&amp;DB=EPODOC&amp;CC=EP&amp;NR=0205969A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19890419&amp;DB=EPODOC&amp;CC=EP&amp;NR=0205969A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GALAMBOS, GEZA</creatorcontrib><creatorcontrib>PAPP, GYULA</creatorcontrib><creatorcontrib>HADHAZY, PAL</creatorcontrib><creatorcontrib>KANAI, KAROLY</creatorcontrib><creatorcontrib>UDVARY, EVA</creatorcontrib><creatorcontrib>MARTON, JENO</creatorcontrib><creatorcontrib>KOVACS, GABOR</creatorcontrib><creatorcontrib>GYORY, PETER</creatorcontrib><creatorcontrib>TOMOSKOZI, ISTVAN</creatorcontrib><creatorcontrib>SZEKERES, LASZLO</creatorcontrib><creatorcontrib>KORMOCZY, PETER</creatorcontrib><creatorcontrib>STADLER, ISTVAN</creatorcontrib><creatorcontrib>DORMAN, GYORGY</creatorcontrib><title>7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM</title><description>The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbtxIeod5gAGSotKl0M6NgNtMiQpuJFSJK5EC_X-aMEDuPo83vvr7HpS7uKUNFwoEkO1Z0sQsI1hD9EQexBPgh4jOwtoaxCDvkNNfWSNLWjXiQu86PAFG5Et22Y5d9tsdR8fc9r9dpPBmaI2Kk2vIc3TeEvP9B5I8iI_VMcKy_KP5AN_MjJR</recordid><startdate>19890419</startdate><enddate>19890419</enddate><creator>GALAMBOS, GEZA</creator><creator>PAPP, GYULA</creator><creator>HADHAZY, PAL</creator><creator>KANAI, KAROLY</creator><creator>UDVARY, EVA</creator><creator>MARTON, JENO</creator><creator>KOVACS, GABOR</creator><creator>GYORY, PETER</creator><creator>TOMOSKOZI, ISTVAN</creator><creator>SZEKERES, LASZLO</creator><creator>KORMOCZY, PETER</creator><creator>STADLER, ISTVAN</creator><creator>DORMAN, GYORGY</creator><scope>EVB</scope></search><sort><creationdate>19890419</creationdate><title>7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM</title><author>GALAMBOS, GEZA ; PAPP, GYULA ; HADHAZY, PAL ; KANAI, KAROLY ; UDVARY, EVA ; MARTON, JENO ; KOVACS, GABOR ; GYORY, PETER ; TOMOSKOZI, ISTVAN ; SZEKERES, LASZLO ; KORMOCZY, PETER ; STADLER, ISTVAN ; DORMAN, GYORGY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0205969A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1989</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GALAMBOS, GEZA</creatorcontrib><creatorcontrib>PAPP, GYULA</creatorcontrib><creatorcontrib>HADHAZY, PAL</creatorcontrib><creatorcontrib>KANAI, KAROLY</creatorcontrib><creatorcontrib>UDVARY, EVA</creatorcontrib><creatorcontrib>MARTON, JENO</creatorcontrib><creatorcontrib>KOVACS, GABOR</creatorcontrib><creatorcontrib>GYORY, PETER</creatorcontrib><creatorcontrib>TOMOSKOZI, ISTVAN</creatorcontrib><creatorcontrib>SZEKERES, LASZLO</creatorcontrib><creatorcontrib>KORMOCZY, PETER</creatorcontrib><creatorcontrib>STADLER, ISTVAN</creatorcontrib><creatorcontrib>DORMAN, GYORGY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GALAMBOS, GEZA</au><au>PAPP, GYULA</au><au>HADHAZY, PAL</au><au>KANAI, KAROLY</au><au>UDVARY, EVA</au><au>MARTON, JENO</au><au>KOVACS, GABOR</au><au>GYORY, PETER</au><au>TOMOSKOZI, ISTVAN</au><au>SZEKERES, LASZLO</au><au>KORMOCZY, PETER</au><au>STADLER, ISTVAN</au><au>DORMAN, GYORGY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM</title><date>1989-04-19</date><risdate>1989</risdate><abstract>The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record>
fulltext fulltext_linktorsrc
identifier
ispartof
issn
language eng ; ger
recordid cdi_epo_espacenet_EP0205969A3
source esp@cenet
subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title 7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-14T08%3A31%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=GALAMBOS,%20GEZA&rft.date=1989-04-19&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP0205969A3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true