7-OXO-PGI2-EPHEDRINE SALTS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to new 7-oxo-PGI2-ephedrine salt analogues of the Formula I wherein A stands for -(CH2)2-, cis or trans -CH=CH- or -C 3BOND C-; R1 is lower alkyl or hydrogen; B represents a chemical bond, -CH2- or -CR2R3; R2 stands for lower alkyl or hydrogen; R3 represents lower alkyl or hydrogen; X is a chemical bond, -O- or -CH2-; R4 stands for C1-6 alkyl, C4-7 cycloalkyl, C1-6 fluoroalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, substituted phenyl or heteroaryl. The salts of the Formula I show the same pharmacological profile as the sodium salt of PGI2, they inhibit blood aggregation and the secretion of gastric acid, are useful in the prevention of anginal attacks. Accordingly the salts of the present invention are useful in the prevention of peripheral vascular diseases, in improving circulation of extremities, in relieving the seriousness of cardiac infarction and also in the treatment and prevention of gastrointestinal ulcer and acute or chronical liver injury.