Oxidation resistant IL-2 muteins and their production, formulations containing such muteins, and DNA sequences and expression vectors coding for such muteins and corresponding transformed host cells

A biologically active reference (e.g. human) IL-2 (interleukin-2) protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation and wherein additional, non-susceptible methionine resid...

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Bibliographische Detailangaben
Hauptverfasser:	KOTHS, KIRSTON EDWARD, HALENBECK, ROBERT FORGAN, INNIS, MICHAEL ALLAN
Format:	Patent
Sprache:	eng ; fre ; ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF COMPOUNDS OF UNKNOWN CONSTITUTION CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	A biologically active reference (e.g. human) IL-2 (interleukin-2) protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionine residue susceptible to chloramine T or peroxide oxidation and wherein additional, non-susceptible methionine residues are not so substituted.