Resolution of racemic mixtures of aliphatic acid esters

Racemic mixtures of partially water-soluble esters defined by the formulawherein R and R1 represent hydrogen and C,-C4 alkyl;R2 represents C1-C4 alkyl andX represents halogen, aliphatic or aromatic groups and substituted derivatives thereofwherein R, R1 and X are different can be resolved by reducin...

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Hauptverfasser: SIUTA-MANGANO, PATRICIA, DAHOD, SAMUN K
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Racemic mixtures of partially water-soluble esters defined by the formulawherein R and R1 represent hydrogen and C,-C4 alkyl;R2 represents C1-C4 alkyl andX represents halogen, aliphatic or aromatic groups and substituted derivatives thereofwherein R, R1 and X are different can be resolved by reducing the water solubility of a racemic mixture of said esters by means other than changing the chemical composition of the ester, contacting the racemic mixture of esters of reduced water solubility with a lipase enzyme from Candida cylindracea capable of stereospecifically resolving the racemic mixture by hydrolysis and stereospecifically resolving the racemic mixture.