DOPAMINE-BETA-HYDROXYLASE INHIBITORS

DOPAMINE-BETA-HYDROXYLASE INHIBITORS

Compounds of structure in which Y is -CH2NH2 or SR; R is hydrogen or C1-4 alkyl; n is 0 to 5; and R to R are the same or different and are each hydrogen, halogen, hydroxy, C1-4 alkyl, CN, NO2, SO2NH2, CO2H, CONH2, CHO, CH2OH, CF3, C1-4 alkoxy, SO2C1-4 fluoroalkyl or CO2C1-4 alkyl; processes for thei...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: KRUSE, LAWRENCE IVAN, KAISER, CARL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds of structure in which Y is -CH2NH2 or SR; R is hydrogen or C1-4 alkyl; n is 0 to 5; and R to R are the same or different and are each hydrogen, halogen, hydroxy, C1-4 alkyl, CN, NO2, SO2NH2, CO2H, CONH2, CHO, CH2OH, CF3, C1-4 alkoxy, SO2C1-4 fluoroalkyl or CO2C1-4 alkyl; processes for their preparation, pharmaceutical compositions containing them and their use in therapy, for example, as anti-hypertensive agents.