6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF

6-PURINYL N-(2-CHLOROETHYL) CARBAMATE AND THIOCARBAMATE, A PROCESS FOR THEIR PREPARATION AND USE THEREOF

The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respect...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BEITOVA, MARTA, GRIMOVA, JAROSLAVA, MUCSC, CERNY, ANTONIN, RNCSC, KREPELKA, JIRI CSC, MELKA, MILAN, MURNDR, MILKO, MILAN, DOC. CSC, POKORNA, STANISLAVA, REICHLOVA, RUZENA, KEJHOVA, IRENA
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to 6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate of the general formula I …… in which X stands for an oxygen or sulphur atom, and to a process for their preparation by reacting a purine derivative of the general formula II …… (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently provide a potential treatment for malignant neoplastic diseases in mammals.