2-oxa-spirocyclic-benzeneacetamides and benzamides

A compound of the formula …… wherein the stereochemistry at the spiro carbon atom is either of the two possible orientations;… each wavy line independently indicates cis or trans relationship of the respective nitrogen-containing substituent with respect to the cycloalkyl ring;… wherein p is 0, 1, 2, 3 or 4 and n is 0, 1, 2, 3 or 4, and the cycloalkyl ring containing them has 5, 6 or 7 carbon atoms;… m is 2 or 3;… A is a bond, -(CH2)q- wherein q is an integer of 1 to 4, or -CH(CH3)-;… X and Y are independently selected from H, F, Cl, Br, CF3, NO2, OH, OCH3, azido, C1-3 alkyl, phenyl, methanesulfonyl, cyano, amino, (C1-3 alkoxy)carbonyl, C-3 alkanoyloxy and C1-3 carboxacylamino;… R is H or C1-3 alkyl;… either R1 and R2 are independently selected from H, C1-3 alkyl and 2-propen-1-yl, or NR1R2 is 1-azetidinyl, 1-pyrrolidinyl or 1-piperidinyl; and… E is oxygen or sulfur;… or a pharmacologically-acceptable salt thereof. … Such compounds can have therapeutic utility.