17-ALPHA-(ARYLOXY OR ALKOXY) ANDROSTENES

Antiglucocorticoid activity is exhibited by new steroids having the formula and the 1,2-dehydro derivatives thereof, wherein R1 is aryl or alkyl; R2 is hydrogen, hydroxy, alkyl, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen; R3 is carboxyl or beta -hydroxyme...

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Bibliographische Detailangaben
1. Verfasser:	HAUGWITZ, RUDIGER D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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Beschreibung
Zusammenfassung:	Antiglucocorticoid activity is exhibited by new steroids having the formula and the 1,2-dehydro derivatives thereof, wherein R1 is aryl or alkyl; R2 is hydrogen, hydroxy, alkyl, alkoxy, aryloxy, oxo, methylene, alkylthio, arylthio, alkanoyl, alkanoyloxy, or halogen; R3 is carboxyl or beta -hydroxymethylene; R4 is hydrogen or halogen; and R5 is hydrogen, fluorine or methyl, wherein the term refers to phenyl and phenyl substituted with 1,2 or 3 alkyl, alkoxy or halogen atoms.