NEW PROCESS FOR THE SYNTHESIS OF PYRIDO-IMIDAZO-REFAMYCINS

A new process for the synthesis of pyrido-imidazo-rifamycins of formulawherein R is hydrogen or acetyl, R, and R2 independently represent hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1-3)-alkylamino-(C1-4)-alkyl. (C1-3)-alkoxy-(C1-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, ni...

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Bibliographische Detailangaben
Hauptverfasser:	CANNATA, VINCENZO, PIANI, SILVANO, TAMAGNONE, GIAN FRANCO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	A new process for the synthesis of pyrido-imidazo-rifamycins of formulawherein R is hydrogen or acetyl, R, and R2 independently represent hydrogen, (C1-4)-alkyl, benzyloxy, mono- or di-(C1-3)-alkylamino-(C1-4)-alkyl. (C1-3)-alkoxy-(C1-4)-alkyl, hydroxymethyl, hydroxy-(C2-4)-alkyl, cyano, halogen, nitro, mercapto, (C1-4)-alkylthio, phenylthio, carbamoyl, mono- or di-(C1-4)-alkyl-carbamoyl, or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups.The process comprises reacting the rifamycin 0 of(Continuation next page) with a 2-aminopyridine of formulawherein R1 and R2 have the same meanings as before.