N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position
Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R...
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| creator | SHANKLIN, JAMES ROBERT, JR |
| description | Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts are useful as cardiac antiarrhythmia agents. Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A )p-X-(A )d-Q side chain are also disclosed. |
| format | Patent |
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Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A )p-X-(A )d-Q side chain are also disclosed.</description><edition>4</edition><language>eng ; fre ; ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1985</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851106&DB=EPODOC&CC=EP&NR=0160436A2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19851106&DB=EPODOC&CC=EP&NR=0160436A2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SHANKLIN, JAMES ROBERT, JR</creatorcontrib><title>N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position</title><description>Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts are useful as cardiac antiarrhythmia agents. Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A )p-X-(A )d-Q side chain are also disclosed.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1985</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNi0EKwjAQRbtxIeodZtmCAbWl-yIVV-LCvUQ7kqFpJiQp6m08gKfwZEYRdOnq897_f5jcNuJxT6uODGeVbq8axFzYq3OsqSGDU4hIFt2bQJomCsUdf-VRugNfZEcNekhfi6CIf20GZwoKfK-t6h1oMi02EQ8-UOgDsQEy8YWwmEIO7KAQlj29mnEyOEntcfLJUQKrerdcC7S8R2_lEQ2Gfb2dzctZkZfVIv9j8gTkMVOf</recordid><startdate>19851106</startdate><enddate>19851106</enddate><creator>SHANKLIN, JAMES ROBERT, JR</creator><scope>EVB</scope></search><sort><creationdate>19851106</creationdate><title>N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position</title><author>SHANKLIN, JAMES ROBERT, JR</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0160436A23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1985</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SHANKLIN, JAMES ROBERT, JR</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SHANKLIN, JAMES ROBERT, JR</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position</title><date>1985-11-06</date><risdate>1985</risdate><abstract>Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts are useful as cardiac antiarrhythmia agents. Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A )p-X-(A )d-Q side chain are also disclosed.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position |
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