N-¬(Amino)Alkyl -1-pyrrolidine, 1-piperidine and 1-homopiperidinecarboxamides (and thiocarboxamides) with sulphur linked substitution in the 2, 3 or 4-position

Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R...

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Bibliographische Detailangaben
1. Verfasser: SHANKLIN, JAMES ROBERT, JR
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Pyrrolidine, piperidine and homopiperidinecarboxamide and thiocarboxamide compounds of the formula: wherein X is -S-, -S(O)- or -S(O)2-; A is a loweralkalene chain and A and A are alkalene chains when p and d are one; R, R and R are hydrogen, loweralkyl, phenyl cycloalkyl or phenylalkyl and R and R may form a heterocyclic residue with the adjacent nitrogen atom; Q is a selected aromatic radical, and the pharmaceutically acceptable acid addition salts are useful as cardiac antiarrhythmia agents. Chemical intermediates, unsubstituted on pyrrolidine, piperidine and homopiperidine nitrogen but with the -(A )p-X-(A )d-Q side chain are also disclosed.