EXPRESSION OF PLASMODIUM FALCIPARUM POLYPEPTIDES FROM CLONED CDNA

DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of Plasmodium falciparum messenger RNA (mRNA) or genomic DNA (gDNA). Especially DNA molecules comprising artificially constructed polynucleotide sequences coding for the whole o...

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Bibliographische Detailangaben
Hauptverfasser:	COWMAN, ALAN, FREDERICK, ANDERS, ROBIN, FREDRIC, BROWN, GRAHAM, VALLANCEY, COPPEL, ROSS, LEON, MITCHELL, GRAHAM, FRANK, KEMP, DAVID, JAMES, SAINT, ROBERT, BRYCE
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY BLASTING CHEMISTRY COMBUSTION ENGINES COMBUSTION ENGINES IN GENERAL COMPOSITIONS THEREOF COMPOUNDS OF UNKNOWN CONSTITUTION CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HEATING HOT-GAS OR COMBUSTION-PRODUCT ENGINE PLANTS HUMAN NECESSITIES HYGIENE INTERNAL-COMBUSTION PISTON ENGINES LIGHTING MECHANICAL ENGINEERING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WEAPONS WINE
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Beschreibung
Zusammenfassung:	DNA molecules comprising artificially constructed polynucleotide sequences substantially corresponding to all or a portion of Plasmodium falciparum messenger RNA (mRNA) or genomic DNA (gDNA). Especially DNA molecules comprising artificially constructed polynucleotide sequences coding for the whole or part of one or more proteins occuring in P. falciparum, or a precursor or modification thereof. Such DNA molecules are capable of being expressed as a polypeptide(s). Synthetic peptides or polypeptides displaying the antigenicity of all or a portion of at least one P. falciparum antigen. Compositions for stimulating immune responses against P. falciparum antigens in a mammal, comprising at least one polypeptide displaying the antigenicity of a P. falciparum antigen, together with a pharmaceutically acceptable carrier therefor.