1,6-NAPHTHYRIDINONE DERIVATIVES, PROCESS FOR THEIR PREPARATION, AND MEDICAMENTS CONTAINING THEM

1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) Naphthyridinone derivatives of the general formula I see diagramm : EP0133530,P12,F4 wherein R**1 is a phenyl radical, which in 2- and/or 3-position may be substituted by halogen atoms, such as fluorine, chlorine or brom...

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Hauptverfasser: MANNHARDT, KARL, KLEINSCHROTH, JURGEN, HERRMANN, MANFRED, FRITSCHI, EDGAR, TAUSCHEL, HORST-DIETMAR, WOLF, GUNTER, SATZINGER, GERHARD, HARTENSTEIN, JOHANNES, WAGNER, BERND
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Sprache:eng ; ger
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Zusammenfassung:1. Claims (for the Contracting States : BE, CH, DE, FR, GB, IT, LI, LU, NL, SE) Naphthyridinone derivatives of the general formula I see diagramm : EP0133530,P12,F4 wherein R**1 is a phenyl radical, which in 2- and/or 3-position may be substituted by halogen atoms, such as fluorine, chlorine or bromine, by nitro, trifluoromethyl, methoxy, difluoromethoxy, or cyano groups or lower alkylamino groups, preferably dimethylamino groups or diethylamino groups, or represents an unsubstituted pyridyl or thienyl radical, R**2 is hydrogen, an alkyl or alkylaminoalkyl group of the general formula II see diagramm : EP0133530,P13,F1 wherein R**5 and R**6 may be the same or different and represent a straight-chained or branched alkyl group with 1-4 C-atoms or represent together an alkylene group with 4-6 C-atoms, n represents the figure 2 or 3, R**3 is an amino group or a methyl or ethyl group and R**4 represents hydrogen or a straight-chained, branched or cyclic alkyl or alkoxyalkyl radical containing up to 6 carbon atoms, as well as optionally the pharmacologically safe salts thereof. 1. Claim (for the Contracting State AT) Process for the preparation of 1,6-naphthyridinone-derivatives of the general formula I see diagramm : EP0133530,P14,F4 wherein R**1 is a phenyl radical, which in 2- and/or 3-position may be substituted by halogen atoms, such as fluorine, chlorine or bromine, by nitro, trifluoromethyl, methoxy, difluoromethoxy, or cyano groups or lower alkylamino groups, preferably dimethylamino groups or diethylamino groups, or represents an unsubstituted pyridyl or thienyl radical, R**2 is hydrogen, an alkyl or alkylaminoalkyl group of the general formula II see diagramm : EP0133530,P15,F1 wherein R**5 and R**6 may be the same or different and represent a straight-chained or branched alkyl group with 1-4 C-atoms or represent together an alkylene group with 4-6 C-atoms, n represents the figure 2 or 3, R**3 is an amino group or a methyl or ethyl group and R**4 represents hydrogen or a straight-chained, branched or cyclic alkyl or alkoxyalkyl radical containing up to 6 carbon atoms, as well as optionally the pharmacologically safe salts thereof, characterized in that either a) 2,4-dihydroxypyridine is reacted in the presence of ammonia with a compound of the general formula III see diagramm : EP0133530,P15,F2 wherein R**1 , R**3 and R**4 have the aforementioned meaning, and the compounds so obtained of the general formula IV see diagramm : EP0133530,P15,F3 wherein R*