Injection of anti-idiotype to elecit immune response to infectious viral agents

Anti-ID antibodies modulate the immune response to HBsAg. Injection of anti-ID antibodies alone induce anti-HBs that are directed against the a determinant and inhibit a common interspecies anti-HBs ID-anti-ID reaction. In addition, anti-ID treatment prior to HBsAg on synthetic peptide stimulation e...

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Hauptverfasser: KENNEDY, RONALD CURTIS, DREESMAN, GORDON RONALD, MELNICK, JOSEPH LOUIS
Format: Patent
Sprache:eng ; fre ; ger
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Zusammenfassung:Anti-ID antibodies modulate the immune response to HBsAg. Injection of anti-ID antibodies alone induce anti-HBs that are directed against the a determinant and inhibit a common interspecies anti-HBs ID-anti-ID reaction. In addition, anti-ID treatment prior to HBsAg on synthetic peptide stimulation enhance the anti-HBs response. Thus, the immune response to HBV may be controlled via idiotype networks with anti-ID antibodies as vaccine candidates by modulating the immune response to an infections viral agent.